In this section you will find all information relating to the UC sequences even outside of our research laboratory. Paper and news about it will be posted below.
Articles and Papers
UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
One hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species...Read more>>
Ultraconserved elements (Bejerano laboratory)
As their name implies, ultraconserved elements (UCEs) are highly conserved regions of organismal genomes shared among evolutionary distant taxa - for instance, birds share many UCEs with humans. UCEs were first described in a wonderful manuscript by Gil Bejerano et al. (2004) from David Haussler’s group and subsequently identified in several classes of organisms outside the group of original taxa (Siepel et al. 2005) used to identify these genomic elements. The 27-way vertebrate genome alignment (Miller et al. 2007) identified additional regions of high conservation.Read more>>
UCNEbase--a database of ultraconserved non-coding elements and genomic regulatory blocks.
UCNEbase (http://ccg.vital-it.ch/UCNEbase) is a free, web-accessible information resource on the evolution and genomic organization of ultra-conserved non-coding elements (UCNEs). It currently covers 4351 such elements in 18 different species. The majority of UCNEs are supposed to be transcriptional regulators of key developmental genes. As most of them occur as clusters near potential target genes, the database is organized along two hierarchical levels: individual UCNEs and ultra-conserved genomic regulatory blocks (UGRBs). UCNEbase introduces a coherent nomenclature for UCNEs reflecting their respective associations with likely target genes. Orthologous and paralogous UCNEs share components of their names and are systematically cross-linked. Detailed synteny maps between the human and other genomes are provided for all UGRBs. UCNEbase is managed by a relational database system and can be accessed by a variety of web-based query pages. As it relies on the UCSC genome browser as visualization platform, a large part of its data content is also available as browser viewable custom track files. UCNEbase is potentially useful to any computational, experimental or evolutionary biologist interested in conserved non-coding DNA elements in vertebrates.Read more>>